The train, which was carrying 186 passengers, was travelling on Friday between the Normandy cities of Rouen and Caen when it derailed at about 7:45pm (17:45 GMT), French Transport Minister Philippe Tabarot said on X.
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Local authorities said they had activated a mass-casualty response plan, deploying 130 firefighters, five medical teams and 80 vehicles to the scene.
Rouen prosecutor Sebastien Gallois said 44 people were injured, including an 18-year-old woman who was evacuated in “critical condition”.
According to the prefecture of Seine-Maritime, the young woman was evacuated by helicopter to Rouen University Hospital.
One passenger, Louis, 24, told local radio ICI Normandie: “Suddenly there were a few jolts, and then after about three seconds it got stronger and stronger.”.
SNCF Reseau, which manages France’s rail network, said traffic on the line had been suspended and power to the tracks was cut to allow emergency services to operate.
Gallois said tests for drugs and alcohol on the train driver had come back negative.
Rail authorities and police are investigating the cause of the derailment.
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